Ketamine had a controversial history over the years, used initially for pain management and anesthesia in the 1960s, then considered to be a “drug of abuse” and finally now one of the biggest breakthroughs in the treatment of severe depression.

“Outside of the clinic, ketamine can cause tragedies, but in the right hands, it is a miracle,” says John Abenstein, MD, president of the American Society of Anesthesiologists.